Proteolytic Enzymes as Therapeutic Targets
نویسنده
چکیده
treat acquired immunodeficiency syndrome [AIDS]) and against the angiotensin-converting enzyme (ACE) (to treat hypertension) are the only protease inhibitors approved by the FDA for therapeutic use (see Table 1). HIV-1 protease is an aspartic protease that is necessary for the processing of viral polypeptides late in the viral replicative cycle. Inhibition of this activity prevents formation of functional viral peptides and, thus, formation of infectious virions (1). The ACE, a zinc metalloprotease, controls formation of angiotensin II by proteolytic processing of Proteolytic Enzymes as Therapeutic Targets
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